职称/职务

副教授,系党支部书记

研究方向

药物化学生物学

邮箱

xinyahan@ahut.edu.cn; xinyah@126.com

学习工作经历

2016.6-至今：安徽工业大学，英国正版365官方网站化学生物学与制药工程系，讲师、副教授

2010.9-2016.6：华中师范大学，化学学院，有机化学专业，理学博士

2006.9-2010.6：青岛农业大学，化学与药学院，制药工程专业，工学学士

主要科研项目及成果

博士生导师，省级青年拔尖人才，安徽省高校杰出青年科研项目获得者，安徽省优秀青年研究生导师，安徽工业大学青年学者（A档）。主要从事药物化学生物学与生物材料研究，先后主持国家重点研发计划政府间国际科技创新合作重点专项任务、国家自然科学基金青年项目等国家级项目4项、安徽省高校杰出青年科研项目、安徽省重点研究与开发计划项目等省部级项目4项；负责科技部发展中国家杰出青年科学家来华工作计划2项；以第一作者或通讯作者在Org. Lett., Sensor Actuat. B-CHEM. Eur. J. Med. Chem.等国际知名期刊发表高质量论文26篇，授权国家发明专利8项；获安徽省教学成果奖特等奖、一等奖、三等奖各1项，主持省级课程思政示范课1门、省级研究生国际学术论坛1项。 

近期主持的部分科研项目：

1 国家重点研发计划政府间国际科技创新合作重点专项任务，2017YFE0118200，2019.1-2022.12，108万，已结题，主持

2 国家自然基金委国际(地区)合作与交流项目任务，32061143045，2021.01-2023.12，50万，在研，主持

3 国家自然科学基金青年项目，82104065，2022.01-2024.12，30万，在研，主持

4 安徽省高校杰出青年科研项目，2022AH020035，2022.12-2025.11，100万，在研，主持

5 科技部中国--匈牙利科技合作交流项目，2018-II-2，2020.1-2021.12，10万，在研，主持

6 科技部中国--乌克兰科技合作交流项目，CU03-04，8万，2020.1-2021.12，在研，主持

7 安徽省重点研究与开发计划项目，201904b11020025，2019.1-2021.12，30万，已结题，主持

8 安徽省自然基金面上项目，1908085MB35，2019.7-2022.6，10万，已结题，主持

9 科技部发展中国家杰出青年科学家来华工作计划，越南-18-001，2019.1-2019.12，15万，已结题，负责人

10 安徽省高等学校自然科学研究项目（重点项目），KJ2018A0040，6万，2018.1-2019.12，已结题，主持

11 微生物技术国家重点实验室开放课题，M2017-11，10万，2017.10-2019.9，已结题，主持

12 农药与化学生物学教育部重点实验室开放课题，201801A02，9万，2019.1-2021.12，已结题，主持

13 理论有机化学与功能分子教育部重点实验室开放课题，LKF1401，1.5万，2017.1-2018.12，已结题，主持

14 安徽工业大学校青年基金项目，QZ201609，0.8万，2017.1-2018.12，已结题，主持

15 安徽工业大学人才引进科研启动经费，10万，在研，主持

近期发表的部分论文:

1) Qian Chen, Jiaxu Liu, Shenjun Liu, Jian Zhang, Lifang He, Renyong Liu, Hui Jiang, Xiaya Han* and Kui Zhang*, Visual and Rapid Detection of Nerve Agent Mimics in Gas and Solution Phase by a Simple Fluorescent Probe, Anal. Chem. 2023, 95: 4390-4394.

2) Xinya Han, Qinfei Xia, Qi Wang, Xiaolong Ding, Qinghe Gao , Yiliang Chen, Jiaxu Liu, Jufen Yan, Qi Sun*, Qian Chen*, and Kui Zhang, A highly selective and sensitive hydrogen sulfide scavenger along with its imaging in cells and zebrafish, Sensor Actuat. B-CHEM., 2023, 379: 133169.

3) Qinghe Gao*, Zhenhua Sun, Manman Wu, Yimei Guo, Xinya Han*, Jufen Yan, Minh Ngoc Ha, Quynh Mai Le and Yongtao Xu*, Di-tert-butyl peroxide as an effective two-carbon unit in oxidative radical cyclization toward 7-methylazolo[1,5-a]pyrimidines, Org. Chem. Front. 2022, 9, 3050.

4) Huan Qin, Xiaolong Ding, Shi-Qi Cheng, Siyong Qin*, Xinya Han*, Yue Sun*, Yi Liu, A H₂S-regulated artificial nanochannel fabricated by supramolecular coordination strategy, J. Phys. Chem. Lett., 2022, 13, 9232-9237.

5) Qinghe Gao^#, Zhenhua Sun^#, Qinfei Xia^#, Ruonan Li, Wenlong Wang, Siwei Ma, Yixin Chai, Manman Wu, Wei Hu, Péter Ábrányi-Balogh, György M. Keserű, and Xinya Han*, Vinylation of α‑Aminoazoles with Triethylamine: A General Strategy to Construct Azolo[1,5-a]pyrimidines with a Nonsubstituted Ethylidene Fragment, Org. Lett. 2021, 23, 2664−2669.

6) Qian Chen, Yudie Sun, Shengjun Liu, Jian Zhang, Cheng Zhang, Hui Jiang, Xinya Han*, Lifang He, Suhua Wang, Kui Zhang*, Colorimetric and fluorescent sensors for detection of nerve agents and organophosphorus pesticides, Sensor Actuat. B-CHEM.,2021,344: 130278.

7) Xinya Han, Yunyuan Huang, Lin Wei, Haifeng Chen, Yanrong Guo, Zilong Tang, Wei Hu, Qinfei Xia, Qi Wang, Jufen Yan*, Yanliang Ren*, Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase, Bioorg. Med. Chem. 2020, 28: 115624.

8) Qi Sun^#, Yuan Qiu^#, Jun Chen, Fengshou Wu, Xiaogang Luo, Yanrong Guo, Xinya Han*, Dawei Wang*, A colorimetric and fluorescence turn-on probe for the detection of palladium in aqueous solution and its application in vitro and in vivo, Spectrochim. Acta Part A 2020, 239, 118547.

9) Ling Jin, Li Zhang, Lei Yang, Xingrong Wua, Cheng Zhang, Kang Wei, Lifang He, Xinya Han*, Hongbin Qiao*, Abdullah M. Asiri, Khalid A. Alamry, and Kui Zhang*, Orange-Red, Green, and Blue Fluorescence Carbon Dots for White Light Emitting Diodes, J. Mater. Sci. Technol. 2020, 50, 184-191.

10) Jun Tang, Yali Cao, Fei Ruan, Fengfeng Li, Yangxin Jin, Minh Ngoc Ha, Xinya Han*, and Qingping Ke*, New Approach for Controllable Synthesis of N-MnOx Micro-flowers and Their Superior Catalytic Performance for Benzoxazole Synthesis, Ind. Eng. Chem. Res. 2020, 59, 9408-9413.

11) Zilong Song, Yun Zhu, Jingrui Liu Shuke Guo,Yucheng Gu, Xinya Han*, Hongqiang Dong, Qi Sun, Weihua Zhang*, Mingzhi Zhang*, Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety, Mol. Divers. 2020, https://doi.org/10.1007/s11030-020-10048-8

12) Yunyuan Huang^#, Lin Wei^#, Xinya Han^#, Haifeng Chen^#, Yanliang Ren*, Yanhong Xu, Rongrong Song, Li Rao, Chen Su, Chao Peng, Lingling Feng, Jian Wan*, Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects, Eur. J. Med. Chem. 2019, 184(15), 111749-11762.

13) Qinghe Gao*^,#, Xinya Han^#, Peiyuan Tong, Zhiang Zhang, Haotian Shen, YanrongGuo, Suping Bai, Aerobic α,β-C(sp3)-H Bond Difunctionalization and C-N BondCleavage of Triethylamine: Difunctional Ammonium Iodide Enablingthe Regioselective Synthesis of 4-Arylpyrimido[1,2-b]indazoles, Org. Lett. 2019, 21 (15), 6074-6078.

14) Xinya Han^#, Xiuyun Zhu^#, Zongqin Hong^#, Lin We, Yanliang Ren*, Fen Wan, Shuaihua Zhu, Hao Peng, Li Guo, Li Rao, Lingling Feng, and Jian Wan*, Structure-Based Rational Design of Novel Inhibitors Against Fructose-1,6-Bisphosphate Aldolase from Candida albicans, J. Chem. Inf. Model. 2017, 57 (6), 1426-1438.

15) Xinya Han^#, Yunyuan Huang^#, Rui Zhang^#, Shan Xiao, Shuaihua Zhu, Nian Qin, Zongqin Hong, Lin Wei, Jiangtao Feng, Yanliang Ren, Lingling Feng*, and Jian Wan*, New Insight into the Binding Modes of TNP-AMP to the Human Liver Fructose-1,6-bisphosphatase, Spectrochim. Acta Part A 2016, 165 (5), 155-160.

16) Xinya Han^#, Xiuyun Zhu^#, Shuaihua Zhu^#, Lin Wei, Li Rao, Zongqin Hong, Li Guo, Haifeng Chen, Bo Chi, Yan Liu, Lingling Feng, Yanliang Ren*, and Jian Wan*, A Rational Design, Synthesis, Biological Evaluation and Structure−Activity Relationship Study of Novel Inhibitors against Cyanobacterial Fructose-1,6-bisphosphate Aldolase, J. Chem. Inf. Model. 2016, 56 (1), 73-81.

17) Haifeng Chen^#, Xinya Han^#, Nian Qin^#, Lin Wei, Yue Yang, Li Rao, Bo Chi, Lingling Feng, Yanliang Ren,* and Jian Wan* Synthesis and Biological Evaluation of β-Nitrostyrene Derivatives as Antifungal Agents Against Magnaporthegrisea, Bioorg. Med. Chem. 2016, 24 (6), 1225-1230.

18) Ding Li^#, Xinya Han^#, QidongTu^#, Lingling Feng, Di Wu, Yao Sun, Haifeng Chen, Yongjian Li, Yanliang Ren,* and Jian Wan*,Structure-Based Design and Synthesis of Novel Dual-TargetInhibitors Against Cyanobacterial Fructose-1,6-Bisphosphate Aldolase and Fructose-1,6- Bisphosphatase, J. Agric. Food Chem. 2013, 61 (31), 7453-7461.